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制备和评估四氨酸纳米晶体以提高生物可用性

Fei Xue1, Lan Yang1, Shuai Ma1

  • 1Institute of Chinese Materia Medica, Chengde Medical University, Hebei Province Key Laboratory of Research and Development for Chinese Materia Medica, Chengde Hebei Province, 067000, P.R. China.

Current drug delivery
|December 26, 2024
PubMed
概括

二烯纳米晶体 (TET-NCs) 已准备好克服不良溶解性和低生物可用性. 这种方法显著增强了TET溶解,生物可用性和细胞抑制效应.

关键词:
二甲氨酸 (tetrandrine) 是一种二甲氨酸.生物可用性 生物可用性纳米晶体是一种纳米晶体.药物动力学 药物动力学准备 准备 准备 准备可溶性和稳定剂的使用.

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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