自身免疫性并发症对多发性硬化症过程的影响:一项多中心观察性研究
Viviana Nociti1, Marina Romozzi1, Luca Prosperini2
1Multiple Sclerosis Research Center 'Anna Paola Batocchi', Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
European journal of neurology
|December 26, 2024
概括
自免疫性并发症 (AC) 在多发性硬化症 (PwMS) 患者中很常见,可能会影响诊断和残疾. 然而,AC似乎没有恶化PwMS的长期预后.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 在患有多发性硬化症 (PwMS) 的人群中,经常观察到自身免疫性并发症 (AC).
- 了解AC对MS进展和治疗的影响对于患者管理至关重要.
- 与MS相关的AC的特征可以为个性化治疗策略提供信息.
研究的目的:
- 调查与AC和没有AC的PwMS诊断时的年龄和残疾.
- 评估AC对没有疾病活动证据-3 (NEDA-3) 状态的影响.
- 为了比较与没有AC的MS患者的治疗方法.
主要方法:
- 一项基于人口的多中心研究,涉及873名复发性复发性多发性硬化症 (RRMS) 患者.
- 患者被分为具有 (AC组) 或没有 (参考组) AC的组.
- 在基线和36个月收集了人口统计,临床特征,治疗,MRI活动,EDSS和NEDA-3状态的数据.
主要成果:
- 24.7%的RRMS患者至少有一次AC.
- 与参考组相比,患有AC的患者在较大年龄被诊断出患有较高残疾分数 (EDSS).
- 与参考组 (干扰素-β,fingolimod) 相比,AC组的失去NEDA-3状态风险较低,并且接受了不同的治疗 (格拉提拉默酸盐,纳塔利祖马布,瑞图西马布).
结论:
- AC在PwMS中很常见,并且与延迟发病,诊断和更高的初始残疾有关.
- 在PwMS中AC的存在与较差的长期预后无关.
- 对于具有共存自身免疫性疾病的MS患者,可以考虑量身定制的治疗策略.
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