内分泌干扰剂和膀功能:酸盐在过度活跃的膀中的作用
Li Liu1, Xia Li1, Xuexue Hao1
1Department of Urology, Tianjin Medical University General Hospital, Tianjin, China.
Frontiers in public health
|December 26, 2024
概括
尿甲酸水平较高,特别是单甲酸 (MBzP) 和单异布甲酸 (MiBP),与过度活性膀 (OAB) 风险增加有关. 这些环境污染物可能在OAB发展中发挥作用.
科学领域:
- 环境健康 环境健康
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 内分泌学 在内分泌学.
背景情况:
- 酸盐是环境中常见的塑化剂和内分泌干扰剂.
- 它们在过度活性膀 (OAB) 病原发生中的作用尚不清楚.
- 需要大规模的流行病学数据来调查甲酸盐暴露和OAB.
研究的目的:
- 检查尿液中甲酸盐度与OAB之间的关联.
- 探索酸盐对OAB的潜在非线性关系和混合作用.
- 确定有助于OAB风险的特定酸盐.
主要方法:
- 使用了国家健康和营养检查调查 (NHANES) 数据 (2011-2018).
- 采用加权多变量后勤回归,受限立方线 (RCS) 和贝叶斯内核机器回归 (BKMR) 分析.
- 研究尿甲代谢物 (MBzP,MiBP) 和OAB之间的关联,包括子组和混合物分析.
主要成果:
- 单乙酸盐 (MBzP) 和单异布乙酸盐 (MiBP) 的较高度与增加OAB风险显著相关.
- RCS分析表明MBzP,MiBP和OAB之间存在线性关系.
- BKMR分析证实了酸盐混合物对OAB的整体积极影响,其中MBzP是主要贡献者.
结论:
- 尿中甲酸盐度与OAB之间存在正相关性.
- MBzP和MiBP是OAB病原发生的潜在贡献者.
- 需要进一步的研究来验证和完善这些关于酸盐和OAB的发现.
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