红细胞分布宽度与白蛋白比率与喘风险有关:基于人口的研究
Jinzhen Ding1,2, Yixiang Zhang1,2, Xiaoyang Chen1,2
1Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Fujian, Quanzhou, Fujian, China.
Frontiers in medicine
|December 26, 2024
概括
红细胞分布宽度与白蛋白比率 (RAR) 是喘的重要危险因素. 较高的RAR水平与患喘的可能性增加有关,有助于临床风险评估.
科学领域:
- 生物标志物和炎症研究研究
- 呼吸系统医学与公共卫生
背景情况:
- 红细胞分布宽度与白蛋白比率 (RAR) 是炎症的新兴生物标志物.
- 喘是一种常见的炎症性呼吸道疾病,具有重大的全球健康影响.
研究的目的:
- 调查红细胞分布宽度与白蛋白比率 (RAR) 与患喘风险之间的关联.
- 为了确定RAR是否是喘发病率的独立风险因素.
主要方法:
- 利用了来自国家健康和营养检查调查 (NHANES) 数据库 (1999-2020) 的数据.
- 采用多变量逻辑回归和受限立方线 (RCS) 分析来评估RAR和喘风险之间的关系.
- 进行了敏感性测试的子组和相互作用分析.
主要成果:
- 对54,161人的分析显示,RAR是喘的独立风险因素.
- 中度和高RAR组的个体分别显示喘风险增加了16%和43%.
- 在RAR中增加0.5个单位几乎使喘风险翻了一番 (OR:1.82,95% CI:1.55-2.12).
结论:
- 这项研究确定了RAR和喘风险之间的正线性相关性.
- 增加的RAR,作为连续或分类变量,显著提高了喘风险.
- 这些发现支持RAR在预测和管理喘发作的临床实用性.
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