暴露于多种内分泌干扰化学物质和与女性不孕症的关联:一个案例对照研究
Xianping Wei1, Na Zhang2, Qingqing Zhu1
1State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
Environment & health (Washington, D.C.)
|December 26, 2024
概括
常见的内分泌干扰化学物质 (EDC) 是类和酸盐等. 在不育妇女中发现了某些EDC的较高水平,这表明EDC暴露与不育风险之间存在联系.
科学领域:
- 环境健康 环境健康
- 生殖毒理学 生殖毒理学
- 流行病学 流行病学
背景情况:
- 内分泌干扰化学物质 (EDC) 在工业产品和日常生活中普遍存在.
- 以前的研究表明EDCs影响生殖健康,但关于不孕不育的流行病学数据有限.
- 主要的EDC包括 parabens (PBs), triclocarban (TCC), triclosan (TCS), bisphenols (BPs), benzophenones (BzPs) 和酸盐代谢产物 (mPAEs) 在内.
研究的目的:
- 调查常见EDC暴露与生育年龄妇女不孕症之间的关联.
- 测量来自受孕和不孕妇女的血清样本中的EDC水平.
- 确定可能与女性不孕症相关的特定EDC.
主要方法:
- 对302名女性 (生殖年龄) 的血清样本进行了六类EDC的分析.
- 在肥沃和不育组之间比较EDC的几何平均 (GM) 度.
- 使用了统计分析,包括二进制物流回归和随机森林.
主要成果:
- 在所有分析的血清样本中检测到EDC,这表明暴露范围广泛.
- 与生育妇女相比,在不孕妇女中观察到PBs,MBs,(TCS+TCC) 和mPAEs的血清度显著更高 (p <0.05).
- 甲酸代谢物 (mPAE),特别是mBP/miBP和mEHP,被确定为导致不孕症的潜在因素.
结论:
- 在生育年龄的妇女中,广泛的EDC暴露被证实.
- 某些EDC的高水平与女性不孕症有关.
- 甲酸代谢产物需要进一步调查,因为它们是不孕不育的潜在风险因素.
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