在患有系统性红斑狼的免疫抑制患者中诊断并发性急性白血病的挑战:一个病例报告
Shaily Agrawal1, Amit K Jangir1, M Yogesh2
1Second-Year MBBS Student, Shri MP Shah Medical College, Jamnagar, Gujarat, India.
Journal of family medicine and primary care
|December 26, 2024
概括
接受免疫抑制剂的全身性红斑狼 (SLE) 患者面临诊断方面的挑战. 这一案例凸显了SLE和急性白血病的罕见同时发生,其中症状可以被掩盖,导致诊断延迟.
科学领域:
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
- 在瘤学瘤学.
背景情况:
- 系统性红斑狼 (SLE) 是一种自身免疫性疾病,涉及自身抗体和免疫复合体.
- 虽然淋巴瘤在SLE中很常见,但急性白血病是一个罕见的关联.
- 在SLE中,免疫抑制治疗可能会使其他疾病的诊断复杂化.
研究的目的:
- 报告一种罕见的急性白血病病例,该病例发生在患有系统性红斑狼的患者身上.
- 突出免疫抑制SLE患者的诊断挑战.
- 强调在出现非特异性症状的SLE患者中考虑血液性恶性瘤的重要性.
主要方法:
- 一个40岁的女性有SLE病史的病例报告.
- 临床表现包括发烧,呼吸障碍和外周.
- 血液学调查显示白细胞症,贫血和血小板缺血.
主要成果:
- 病人被诊断出患有急性白血病.
- 患者在诊断后三天去世.
- 白血病的症状可能被SLE和免疫抑制疗法掩盖.
结论:
- 结核病和急性白血病的同时发生很少见.
- 在免疫抑制的SLE患者中诊断血液性恶性瘤是具有挑战性的.
- 对于出现恶化或异常症状的SLE患者,迅速和彻底的血液学评估至关重要.
更多相关视频
12:04The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
Published on: November 1, 2015
17.3K
06:08Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model
Published on: February 10, 2023
1.2K
相关概念视频
Immunodeficiency Diseases
824
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
824
Disorders of Leukocytes
693
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
693
Cell-mediated Immune Responses
65.1K
Overview
65.1K
Pulmonary Tuberculosis I
198
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
198
