探索饮食因素对肠道椎病的影响:孟德尔的随机化方法
Wangzhao Tian1, Wenwen Yang2, Xiaorui Wang3
1The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture Enshi Hubei China.
Food science & nutrition
|December 26, 2024
概括
饮食习惯会影响肠道分流性疾病 (IDD). 猪肉和鱼类的摄入可能会增加IDD风险,而干果的摄入似乎具有保护性,这表明预防的饮食干预措施.
科学领域:
- 胃肠病学 胃肠病学
- 营养科学 营养科学
- 遗传流行病学遗传流行病学
背景情况:
- 肠道分流性疾病 (IDD) 是一种普遍的胃肠道疾病,受饮食习惯的影响.
- 了解特定食物和IDD之间的因果关系对于公共卫生至关重要.
研究的目的:
- 调查20个与饮食相关的因素与患肠道分流性疾病 (IDD) 的风险之间的因果关系.
主要方法:
- 使用来自英国生物银行和FinnGen生物银行的遗传数据进行了孟德尔随机化 (MR) 分析.
- 分析了IDD病例 (n=33,618) 和对照病例 (n=329,381).
- 使用了反变量加权 (IVW),加权中位数 (WM) 和MR-Egger方法.
主要成果:
- 猪肉摄入量 (β=1.06,p=0.00244) 和非油性鱼类摄入量 (β=0.709,p=0.0449) 与IDD风险有显著的积极关联.
- 油性鱼类摄入量 (β=0.246,p=0.0222) 和干水果摄入量 (β=-0.953,p<0.0001) 也显示出显著的关联.
- 在FDR调整后,猪肉摄入量 (q=0.0244) 和干果摄入量 (q<0.0001) 仍然显著,猪肉增加和干果降低IDD风险.
结论:
- 猪肉消费可能会增加肠道分支管疾病的风险.
- 干果的消费可能会对IDD产生保护作用.
- 饮食修改,特别是减少猪肉和增加干果摄入量,可能有利于IDD的预防和管理.
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