溶性泌尿酸酶等离子体激活受体:用于预测COVID-19患者死亡率的有用标记物
Tushar Sehgal1, Ambika Anand1, Gowtham Vijayabupathy1
1Laboratory Medicine, All India Institute of Medical Sciences, New Delhi, New Delhi, IND.
Cureus
|December 26, 2024
概括
溶性泌尿酸酶等离子体激活受体 (suPAR) 是COVID-19患者的显著预后指标. 住院患者中较高的suPAR水平预测死亡风险增加,有助于临床结果评估.
科学领域:
- 传染性疾病 传染性疾病
- 生物标志物 生物标志物
- 临床医学 临床医学
背景情况:
- 预后指标对于管理住院COVID-19患者至关重要,旨在降低发病率和死亡率.
- 溶性泌尿酸酶等离子体激活受体 (suPAR) 在预测SARS-CoV-2感染的临床结果和呼吸系统衰竭方面表现出潜力.
研究的目的:
- 评估suPAR在COVID-19患者中的预测价值.
- 评估suPAR水平与临床结果 (包括死亡率) 之间的相关性.
主要方法:
- 在新德里进行的一项观察性研究包括21名COVID-19患者和9名对照.
- 在第一,第五和第十天使用ELISA套件测量suPAR水平.
- 收集了患者人口统计,疾病严重程度和死亡率数据.
主要成果:
- 在所有测量日 (p <0.05) 中,COVID-19患者的suPAR水平与对照人群相比显著更高.
- 与幸存者相比,死亡的患者在1,5和10天的suPAR水平明显升高 (p <0.05).
- 一个suPAR切断值≥3.64 ng/ml显示88%的灵敏度和73%的特异性预测死亡率.
结论:
- suPAR是住院COVID-19患者的有价值的预后生物标志物.
- 升高的suPAR水平与增加的死亡风险密切相关.
- suPAR测量可以帮助临床医生识别高风险患者及时进行干预.
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