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Updated: May 8, 2025

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
08:45

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors

Published on: July 17, 2020

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通过蛋白质-蛋白质相互作用来调节氨酸酸酶PTP1B的度调节

Cassandra A Chartier1, Virgil A Woods2,3, Yunyao Xu1

  • 1Department of Chemistry, Columbia University, New York, New York, USA.

Protein science : a publication of the Protein Society
|December 26, 2024
PubMed
概括

适应蛋白 Grb2 的结合全质地增强了铁酸酶 PTP1B 的活性. 这种相互作用取决于PTP1B的富含proline的区域,改变了PTP1B的结构和动态,揭示了细胞信号传递的新调节机制.

关键词:
在Grb2中使用Grb2.这就是PTP1B.在SH3域名中,SH3域名是SH3域名.艾洛斯特菌是所有的质谱测量质谱测量质谱测量质谱测量质量测量质谱测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量蛋白质氨酸酸酶是一种蛋白质氨酸酸酶.蛋白质蛋白质相互作用

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