在接受非心脏手术的老年患者中隐藏的外科手术中风 (精确):前性队列分析
Qianyu Cui1, Weixing Zhao2, Hongyan Chen3
1Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.
Anesthesiology
|December 26, 2024
概括
在接受非心脏手术的老年人中,术后隐蔽中风很常见,约有九分之一的患者受到影响. 这些中风显著增加了术后妄想和长期神经认知衰退的风险.
科学领域:
- 神经学 神经学
- 老年医学 老年医学
- 外科手术的结果
背景情况:
- 术后中风是术后神经认知功能障碍的一个已知的危险因素.
- 接受非心脏手术的老年患者特别容易受到这些并发症的影响.
研究的目的:
- 为了评估在接受非心脏手术的老年患者中术后中风的发生率.
- 确定这些中风与术后神经认知结果之间的关联,包括妄想症和长期衰退.
主要方法:
- 在接受非心脏手术的老年患者中进行的术后隐性中风和认知功能障碍 (PRECISION) 研究招募了934名60岁或以上的患者.
- 在手术后7天内使用磁共振成像 (MRI) 进行前性队列设计,以检测隐藏的中风.
- 评估了手术后妄 (在5天内) 和神经认知衰退 (12个月后).
主要成果:
- 在手术后7天内,共检测到111例 (11.9%) 隐性中风.
- 在1年后,术后妄想发生在12.5%的患者中,神经认知下降发生在18.8%的患者中.
- 隐蔽性中风与妄的几率增加 (aOR 2.18) 和1年的神经认知衰退 (aOR 2.33) 有显著的关联.
结论:
- 大约九分之一的接受重大非心脏手术的老年患者经历了外科手术期间的隐蔽中风.
- 隐蔽的外科手术后中风具有临床意义,使得妄想症和长期认知能力下降的风险增加了一倍以上.
- 这些发现强调了在老年手术患者的外科手术期间识别和管理隐性中风的重要性.
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