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测试组胺H1受体结合部位,以探索连接体结合动力学

Sebastiaan Kuhne1, Reggie Bosma1, Albert J Kooistra1

  • 1Amsterdam Institute of Molecular and Life Sciences (AIMMS), Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.

Journal of medicinal chemistry
|December 26, 2024
PubMed
概括

结构动力学关系分析揭示了在组胺H1受体 (H1R) 增加连接体停留时间 (RT) 的策略. 引入一组碳酸盐增强了RT,但降低了连接体效率,突出了对受体调节的多种方法.

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