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Updated: Jun 4, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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通过同时抑制激酶活性和降解蛋白质来向致癌性RET激酶

Yafeng Wang1, Xueqing Hu2, Shriya Pandey2

  • 1Department of Chemistry, University of South Florida, Tampa, Florida 33620, United States.

Journal of medicinal chemistry
|December 26, 2024
PubMed
概括

一种新的PROTAC降解剂,YW-N-7,同时抑制和消耗瘤原RET蛋白,为RET改变的癌症提供了一种新策略. 这种双重作用增强了抗癌疗效,甚至加强了现有的治疗方法.

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