暴露于挥发性有机化合物的油漆工业工人的呼吸系统症状和肺功能:系统性审查和元分析
Lavanya Sekhar1, Akila Govindarajan Venguidesvarane2, Gayathri Thiruvengadam3
1Department of Physiology, Sri Ramachandra Medical College & Research Institute, Sri Ramachandra Institute of Higher Education and Research(SRIHER), Chennai, Tamil Nadu, India.
暴露于挥发性有机化合物 (VOCs) 的油漆工业工人面临着明显更高的呼吸道症状风险,如咳和喘息障碍. 这一元分析证实,暴露于挥发性有机化合物也会损害肺功能,突出了职业健康的关键问题.
科学领域:
- 职业健康和安全问题 职业健康和安全问题
- 环境医学 环境医学
- 肺部病理学 肺部病理学
背景情况:
- 流行病学研究表明,职业暴露于挥发性有机化合物 (VOCs) 的呼吸道风险.
- 挥发性有机化合物的对涂料工业工人的影响在有组织和无组织部门之间有所不同.
- 需要整合有关该特定劳动力的呼吸系统健康影响的证据.
研究的目的:
- 系统地审查和对暴露于VOCs的油漆工业工人的呼吸系统症状和肺功能进行元分析.
- 评估不同职业部门对影响的差异.
- 量化VOC暴露与呼吸系统不良结果之间的关联.
主要方法:
- 在MEDLINE,Scopus,Web of Science和Google Scholar进行了系统的文献搜索,截至2023年8月.
- 包括23项观察性研究,评估呼吸系统症状和肺功能测试 (PFT).
- 用随机效应模型对12项用于呼吸系统症状的研究和18项用于PFT的研究进行了元分析.
主要成果:
- 在暴露于VOC的油漆工人中,咳 (OR:2.72),呼吸障碍 (OR:3.59),鼻子/喉刺激 (OR:4.5) 和喘息 (OR:2.28) 的几率显著增加.
- 观察到肺功能减弱,FEV1 (SMD: -0.88) 和FEV1/FVC (SMD: -0.97) 显著下降.
- heterogeneity (I2 > 75%) 指出,但统计能力仍然显著;协会因地区和部门而异.
结论:
- 涂料行业中对VOC的职业暴露与呼吸系统症状增加和肺功能受损密切相关.
- 这些发现强调了针对油漆工业工人的职业健康干预措施的必要性.
- 进一步的研究可能会探索VOC影响的区域和部门特异性变化.
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