在一个9个月大的女孩身上,BCG免疫接种部位发生的皮肤质性病
Yuka Okura1, Yasuyoshi Hiramatsu1, Masaki Shimomura1
1Department of Pediatrics, KKR Sapporo Medical Center, Sapporo, Japan.
Immunological medicine
|December 26, 2024
概括
婴儿的皮肤质 (PG) 是罕见的. 这一案例突显了BCG免疫接种后的非典型皮肤反应作为潜在的早期症状,其细胞因子概况与成人PG相似.
科学领域:
- 儿科 儿科 儿科
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
背景情况:
- 皮肤病 (Pyoderma gangrenosum,简称PG) 是一种罕见的中性友皮肤病.
- 婴儿PG异常罕见,报告的病例有限.
- 在Bacillus Calmette-Guérin (BCG) 免疫接种后可能出现非典型的皮肤反应.
研究的目的:
- 为了报告一个罕见的婴儿皮肤病的病例.
- 调查婴儿PG的临床表现,细胞因子概况和遗传因素.
- 突出BCG免疫接种和婴儿PG之间的潜在联系.
主要方法:
- 一个9个月大的女孩的案例报告,她患有PG.
- 在BCG免疫接种后的进展的临床观察.
- 细胞因子分析和遗传分析 (MEFV基因).
- 用静脉注射甲基普雷迪尼索隆和口服普雷迪尼索隆治疗.
主要成果:
- 患者在BCG接种部位出现了快速进展的,并在四肢和部出现了疹.
- 观察到IL-1β,IL-10,IL-17A,IL-6和IL-18的血清水平升高.
- 在MEFV基因中确定了一个异构的R202Q变体.
- 症状通过皮质类固醇治疗得到缓解,并且在停止治疗后没有复发.
结论:
- 在BCG免疫接种后的非典型皮肤反应可能预示着婴儿PG.
- 婴儿PG中的细胞因子概况类似于成人PG的,这表明一种共同的病理生理学.
- 即使在BCG接种疫苗后,早期识别和治疗婴儿PG至关重要.
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