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Updated: Jun 4, 2025

Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy
09:13

Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy

Published on: November 1, 2011

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替代拼接扩大了中国粗的马蝙蝠的抗病毒IFITM剧目

Nelly S C Mak1,2, Jingyan Liu3, Dan Zhang3

  • 1Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, United Kingdom.

PLoS pathogens
|December 26, 2024
PubMed
概括

替代拼接使蝙蝠的干扰素诱导的跨膜蛋白 (IFITM) 多样化,增强它们对像SARS-CoV-2这样的病毒的抗病毒免疫力. 这种进化策略补充了基因重复在塑造天生的免疫力.

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Analysis of Group IV Viral SSHHPS Using In Vitro and In Silico Methods

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Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

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相关概念视频

Alternative RNA Splicing02:18

Alternative RNA Splicing

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A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
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Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
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