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患有口唇裂儿童的神经发育障碍:系统性审查
Benjamin Cook1, Stef Van Bockstaele2, Samuel B Crow3
1Faculty of Life Science and Medicine, King's College London, London, UK. Benjamin.d.cook@kcl.ac.uk.
European child & adolescent psychiatry
|December 26, 2024
概括
患有耳面裂 (OFC) 的儿童患有自闭症谱系障碍 (ASD) 的比例高于一般人群. 注意力缺陷多动症 (ADHD) 的联系不太清楚,孤立的口腔裂和综合性裂带来更高的风险.
科学领域:
- 医学研究 医学研究
- 发育儿科 发育儿科
- 遗传学 遗传学 是一个
背景情况:
- 耳面裂 (OFC) 是一种常见的出生缺陷.
- 需要调查OFC,自闭症谱系障碍 (ASD) 和注意力缺陷多动症障碍 (ADHD) 之间的潜在联系.
研究的目的:
- 系统地审查和总结当前关于ASD和ADHD患有OFC的儿童患病率的数据.
- 为了将这些患病率与一般儿科人口进行比较.
主要方法:
- 在遵守PRISMA指南的基础上进行系统审查.
- 在2024年7月搜索了PubMed/Medline和Embase数据库.
- 包括9项研究,对1025篇论文进行选;计算流行率并与全球/对照数据进行比较.
主要成果:
- 在OFC人群中,自闭症患病率在0-50% (平均2.87%) 之间,明显高于全球平均值的~1%.
- 与全球平均值约5%相比,ADHD患病率在2.34-31.71% (平均3.63%) 之间,差异不那么明显.
- 隔离的口腔裂和综合征裂显示了ASD和ADHD的更高的患病率.
结论:
- 患有OFC的儿童表现出ASD的患病率增加.
- 需要进一步调查OFC和ADHD之间的关联.
- 患有隔离口腔裂或综合性裂的个体可能面临更高的风险,需要进一步研究.
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