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铁酸水合物的成本效益在患有缺铁性贫血的患者中

Mikio Momoeda¹, Kyoko Ito², Sachie Inoue³

¹Aiiku Maternal and Child Health Center, Aiiku Hospital, 1-16-10 Shibaura, Minato-Ku, Tokyo, 105-8321, Japan.

International journal of hematology

|December 26, 2024

概括

铁酸盐水合物 (FC) 是一个成本效益的治疗缺铁性贫血 (IDA) 在日本. 从社会角度来看,切换到FC提供了更好的结果,并节省了成本.

科学领域:

药物经济学药物经济学
血液学血液学血液学
胃肠病学胃肠病学

背景情况:

缺铁性贫血 (IDA) 是一种普遍的疾病,需要有效治疗.
酸铁 (SF) 是一种常见的IDA治疗方法,但可能导致恶心/吐.
铁酸盐水合物 (FC) 为IDA管理提供了一个替代的治疗选择.

研究的目的:

为了评估与酸铁 (SF) 相比,酸铁水合物 (FC) 的成本效益,用于日本的IDA治疗.
评估不同的FC剂量策略和从SF治疗中切换协议.
从付款人和社会的角度来确定FC的经济价值.

主要方法:

一个成本效益分析,比较四个FC治疗策略与标准SF100毫克/天超过26周.
策略包括切换到FC (500毫克或1000毫克/天) 或启动FC (500毫克或1000毫克/天) 对于患有SF诱导的恶心/吐的患者.
经质量调整的寿命年 (QALYs) 和增量成本效益比率 (ICERs) 从付款人的角度计算.
经济建模还纳入了有限的社会视角来评估成本节约潜力.

主要成果:

在所有评估的策略中,FC治疗显示了与SF100 mg/天相比的增量QALY增益.
从付款人的角度来看,切换到500毫克/天 (ICER: 1,107,780日元/QALY) 和1000毫克/天 (ICER: 2,257,477日元/QALY) 的FC是具有成本效益的 (≤ 5,000,000日元/QALY).
从有限的社会角度来看,所有四种FC策略都被发现是占主导地位 (成本更低,效率更高) 或节省成本.

结论:

铁酸盐水合物 (FC) 是日本缺铁性贫血 (IDA) 的一个具有成本效益的治疗选择,特别是在从酸盐 (SF) 转换时.
FC治疗与改善的健康结果和显著的经济效益有关,特别是从社会角度来看.
治疗选择应考虑个体患者的特征,以及成本效益数据,以优化IDA管理.

关键词:

具有成本效益的成本效益.铁酸盐水合物铁酸盐水合物胃肠道不良事件胃肠道不良事件缺铁性贫血是因为缺铁性贫血.口服铁制剂口服铁制剂的使用

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