治疗切除后胃癌复发的危险率:对术后监测的影响
Kyohei Kanematsu1, Yuta Nakayama2, Mie Tanabe2
1Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi Ward, Yokohama, Kanagawa, 241-8515, Japan. kanematsu.1l30m@kanagawa-pho.jp.
概括
胃癌复发风险在手术后的早期达到顶峰,根据阶段而有所不同. 术后监测强度可以根据个体胃癌复发风险进行调整.
科学领域:
- 在瘤学瘤学.
- 外科胃肠道外科手术
- 生物统计学 生物统计学
背景情况:
- 胃癌 (GC) 的最佳术后监测缺乏明确的指导方针.
- 了解胃切除术后的GC复发模式对于有效的后续计划至关重要.
研究的目的:
- 用危险函数分析分析胃切除术后胃癌复发风险趋势.
- 为胃癌手术后的患者建立一个合乎逻辑和有效的监测计划.
主要方法:
- 对2503名接受治愈性GC切除的患者 (2000-2018年) 的回顾性审查.
- 随着时间的推移检查复发风险和临床病理学变量的影响.
主要成果:
- 整体GC复发在11.6%的患者中;在手术后11个月达到峰值风险.
- 第一阶段的GC显示复发风险低;第二阶段达到16个月的峰值;第三阶段达到11个月的峰值.
- 手术后39个月,复发风险显著降低,而第三阶段风险在40个月后停滞.
结论:
- 胃癌复发风险显著依赖于手术后的阶段.
- 监测强度可以根据个体胃癌复发风险概况量身定制.
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