报告给美国中毒中心的Tianeptine暴露,2015-2023年
Mustafa Quadir1,2, Natalie I Rine3, Jaahnavi Badeti1
1Center for Injury Research and Policy, The Abigail Wexner Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, USA.
概括
补充剂中未经批准的抗抑郁药Tianeptine在2015-2023年期间,美国中毒中心暴露率上升了1400%. 大多数案例涉及中度至重大影响,强调需要统一监管.
科学领域:
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
- 药物监督 药物监督 药物监督
背景情况:
- 蒂安尼是一种非典型的三环抗抑郁药,尽管缺乏FDA批准,但在美国的食补充剂中可以获得.
- 这项研究侧重于向中毒控制中心报告的单一物质天胺暴露.
研究的目的:
- 调查2015年至2023年期间报告给美国中毒中心的tianeptine暴露的趋势和特征.
- 为了确定与蒂安尼毒性相关的人口和临床因素.
主要方法:
- 从国家毒素数据系统 (2015-2023) 中分析了TIANEPTINE暴露病例.
- 检查暴露率,临床影响,医疗住院以及滥用和戒断等因素.
主要成果:
- 从2015年到2023年,观察到TIANEPTINE暴露量的1400%增加.
- 超过一半的暴露 (51.5%) 导致中度影响,12%造成严重影响,40.1%需要住院治疗.
- 滥用蒂安尼与增加的不良反应有关,50岁以上的个人面临更高的严重后果风险.
结论:
- 蒂安尼暴露量显著增加,表明其毒性并引起公众健康的关注.
- 为了解决这个日益严重的问题,建议在所有州对蒂安尼的统一监管.
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