在ART怀孕后儿童癌症风险的性别差异:基于注册表的研究
L L Oakley1,2, D Kristjansson1,3, M C Munthe-Kaas1,4
1Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Human reproduction (Oxford, England)
|December 26, 2024
概括
某些辅助生殖技术 (ART) 显示出特定性别的儿童癌症风险,特别是在通过ICSI或冷保存胚胎移植受孕的男孩中. 需要对潜在机制进行进一步研究.
科学领域:
- 生殖医学和儿童健康
- 流行病学和公共卫生.
- 在瘤学瘤学.
背景情况:
- 之前关于辅助生殖技术 (ART) 和儿童癌症风险的研究已经产生了不一致的结果.
- 有限的研究已经研究了在ART怀孕后儿童癌症风险的潜在性别差异.
研究的目的:
- 为了确定ART怀孕后儿童癌症的风险是否因性别而异.
- 探索ART方式与儿童癌症风险之间的特定年龄和性别的关联.
主要方法:
- 一项基于登记册的队列研究包括超过220万名出生在挪威的儿童 (1984-2022).
- 确定了ART受孕 (IVF/ICSI),并与挪威癌症登记处进行了联系.
- 考克斯回归模型分析了ART概念与非ART概念的儿童的年龄和性别特异性癌症风险.
主要成果:
- 在接受ART治疗的儿童中,总体累积癌症发病率高于接受ART治疗的儿童 (每10万人年21.5),而不是接受ART治疗的儿童 (每10万人年17.5).
- 性别分析显示,通过ICSI (aHR 1.69) 或冷保存胚胎移植 (aHR 1.79) 怀孕的男孩的风险增加,但女孩的风险没有增加.
- 在接受ART治疗的儿童中,在5-9岁之间观察到更高的整体癌症风险,特别是在男孩中.
结论:
- 特定年龄和性别的分析显示,在某些通过ART怀孕的群体中,儿童癌症风险增加,这些风险在组合分析中被掩盖.
- 研究结果表明,与ART和儿童癌症相关的潜在的性别特异性机制需要进一步调查.
- 儿童癌症很少见,一些亚型分析可能不足.
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