在国家队列中,叶酸和肺癌死亡之间的时间依赖双向关联在全国队列中
Blessing E Odion1, Logan Cowan, Lili Yu
1Department of Biostatistics, Epidemiology and Environmental Health Sciences, Jiann-Ping Hsu College of Public Health, Georgia Southern University, Statesboro, Georgia, USA.
概括
叶酸是什么意思?叶酸是什么意思?
科学领域:
- 营养流行病学 营养流行病学
- 癌症研究 癌症研究
- 公共卫生 营养 公共卫生 营养
背景情况:
- 由于叶酸强化,叶酸在癌症风险中的作用尚不清楚.
- 人口水平的叶酸摄入量发生了显著的变化.
- 以前的研究被强化效应所混.
研究的目的:
- 调查叶酸水平与肺癌死亡风险之间的关系.
- 为了考虑叶酸强化的影响.
- 检查叶酸对肺癌的时间依赖性影响.
主要方法:
- 利用国家队列 (国家健康和营养检查调查,1988-1994).
- 随访了14528名成年人,平均持续了14年.
- 采用考克斯回归来估计基于血清叶酸水平的LCD危险比率,控制强化.
主要成果:
- 早期随访 (≤10年):中度 (HR=2.87) 和高 (HR=1.56) 血清叶酸的LCD风险增加.
- 后期随访 (>10年): 血清叶酸中等 (HR=0.45) 和高 (HR=0.37) 的LCD风险降低.
- 红细胞叶酸和LCD风险之间没有发现关联.
结论:
- 检测到血清叶酸和肺癌死亡之间的时间依赖的双向关联.
- 表明叶酸在肺癌致癌过程中的双重作用.
- 强调在营养流行病学中考虑强化和时间依赖的影响的重要性.
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