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可能的IgG4相关的轨道疾病被郁的眼睛表面掩盖了伪表皮质瘤性增生症伪表皮质瘤性增生症

Sumer Doctor¹, Vijitha S Vempuluru¹, Dilip K Mishra²

¹The Operation Eyesight Universal Institute for Eye Cancer, Ophthalmic Pathology Laboratory, LV Prasad Eye Institute, Hyderabad, India.

Ophthalmic plastic and reconstructive surgery

|December 26, 2024

概括

免疫球蛋白G4相关的轨道疾病 (IgG4-ROD) 可以模仿侵略性瘤,导致结膜和膜炎症. 这种罕见的疾病可能会出现类似于伪表皮质瘤性增生症的变化,需要进行彻底的调查.

科学领域:

眼科医生眼科眼科
免疫学免疫学免疫学
病理学病理学病理学

背景情况:

免疫球蛋白G4相关疾病 (IgG4-RD) 是一种全身性纤维炎症疾病.
与IgG4相关的轨道疾病 (IgG4-ROD) 通常呈现为轨道中的质量或加厚.
结膜和膜干扰与伪表皮瘤性增生症样变化是一种不寻常的IgG4-ROD表现.

研究的目的:

报告一种罕见的IgG4-ROD病例,呈现出结膜和膜炎症.
突出IgG4-ROD模仿其他轨道病理的潜力,包括侵略性瘤.
强调在炎症轨道病变的差异诊断中考虑IgG4-ROD的重要性.

主要方法:

一个40岁的女性患有结膜质量的病例报告.
最初的活检显示炎症颗粒组织和伪表皮质瘤性增生.
轨道化样本的组织病理学检查显示了广泛的上皮细胞变化和IgG4阳性血细胞透.

主要成果:

患者最初对类固醇有反应,但后来出现了侵略性的轨道延伸和角膜穿孔.
组织病理学证实了广泛的上皮生长下降和单核细胞透,主要是血细胞.
轨道组织中IgG4/IgG比率升高 (34%) 支持诊断可能的IgG4-ROD.

结论:

在很少的情况下,IgG4-ROD可以表现为结膜和膜炎症.
类似于伪表皮瘤性增生症的变化可能是IgG4-ROD的次要现象.
准确的诊断需要进行全面的组织病理学评估,并考虑IgG4染色.

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