在紧急情况下管理急性动的 parenteral ketamine 的系统审查
Christopher Peter1, Satish Suhas1, Guru S Gowda1
1Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Bengaluru, India.
Asian journal of psychiatry
|December 26, 2024
概括
腹腔胺提供了急性激动在紧急情况下的快速和有效的治疗. 这次审查发现胺是一种安全的替代品,尽管建议进一步研究以获得最佳使用.
科学领域:
- 紧急医疗 紧急医疗
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 急性动是一种常见的精神病紧急情况,特别是在精神分裂症或双相情感障碍患者中.
- 目前对急性动荡的管理选择有限,在紧急情况下存在挑战.
- 胺正在成为治疗急性兴奋症的传统抗精神病药物的快速发作的替代品.
研究的目的:
- 系统地审查对内胺的有效性和安全性,以应对紧急情况下的急性动.
- 为了综合有关胺剂的管理,镇静,不良事件和输管率的数据.
主要方法:
- 根据PRISMA指南进行了系统审查,在2024年4月搜索数据库.
- 包含了涉及在紧急环境中对急性激动的肠道胺的研究.
- 数据提取的重点是患者人口统计,胺剂的使用,镇静,不良事件和输管.
主要成果:
- 该审查包括29项研究,涉及1516名患者,主要是男性,平均年龄为35.5岁.
- 胺主要是通过肌肉内注射 (69%),平均剂量为3.83毫克/千克,IV注射是13.5%的2.09毫克/千克.
- 镇静发生在平均6.1分钟内,不良影响包括心跳缓慢,高血压和高唾液;19.1%需要输管,不仅仅归因于胺. 没有观察到精神病症状恶化.
结论:
- 腹腔胺是一种有效和安全的选择,用于在急诊室管理急性激动.
- 进一步的研究是必要的,以优化在这种临床背景下使用胺.
- 胺似乎不会加剧或诱导激动患者的精神病症状.
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