循环RNA和宿主基因在调节骨肌形成中的细胞过程和功能的过程中协同作用
Chiu-Jung Huang1, Kong Bung Choo2
1Department of Animal Science & Graduate Institute of Biotechnology, College of Environmental Planning & Bioresources (former School of Agriculture), Chinese Culture University, Taipei, Taiwan.
Gene
|December 26, 2024
概括
循环RNAs (circRNAs) 和宿主基因共同调节肌肉发育. 这些circRNAs经常隔离microRNAs (miRNAs),增强基因表达和蛋白质生产以形成肌肉.
科学领域:
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
- 发展生物学 发展生物学
背景情况:
- 循环RNAs (circRNAs) 是重要的转录后调节器,其来源于mRNA前的背接.
- circRNAs的主要调节作用包括隔离microRNAs (miRNAs),从而释放被阻断的mRNA进行翻译.
- 骨肌发生,肌肉形成的过程,是一个重要的发育途径,为研究circRNA-宿主基因相互作用提供了一个模型.
研究的目的:
- 审查和解释方法,调节机制和宿主基因和骨肌形成中的circRNAs的协同功能.
- 专注于肌细胞分化和扩散作为肌肉形成的关键驱动因素.
- 简要讨论肌肉组织结构,维护和功能的支持性肌源性过程.
主要方法:
- 文献综述以确定参与骨肌发生的circRNA及其宿主基因.
- 对已识别的circRNA及其调节机制 (miRNA测序或蛋白质翻译) 的分析.
- 检查宿主基因和circRNAs在调节肌体发生和肌肉特异性功能的关系.
主要成果:
- 来自31个宿主基因的32个circRNA被确定在各种肌性阶段.
- 大多数circRNAs (68.6%) 通过隔离miRNAs来调节肌体发生,影响PI3K/AKT等途径.
- 很大一部分宿主基因 (32.3%) 调节肌体发生,其中一些与骨肌功能和疾病有关.
结论:
- 循环RNA和宿主基因在调节细胞过程中表现出协同功能,特别是在骨肌形成中.
- 这种协同相互作用可能会微调基因调节并增强宿主基因功能,可能在miRNAs之后演变.
- 了解这些circRNA-宿主基因关系,可以了解肌肉发育和相关疾病.
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