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来自不同植物来源的本地粉作为MUPS片中的有效辅助缓冲剂
Daniel Robin Thio1, Yu Min Ong1, Natalia Veronica1
1GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy and Pharmaceutical Sciences, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore.
International journal of pharmaceutics
|December 26, 2024
概括
米和塔皮奥卡等本土粉显著减少了在多单元颗粒系统 (MUPS) 平板压缩过程中持续释放颗粒的损伤. 这种简单的填充策略保护了功能性聚合物外层,保持了药物释放.
科学领域:
- 制药技术 制药技术 制药技术
- 材料科学 材料科学 材料科学
背景情况:
- 压缩成多单元颗粒系统 (MUPS) 片可以损坏持续释放颗粒涂层.
- 这种损伤损害了功能性聚合物层和所需的药物释放概况.
- 现有的减缓策略往往涉及复杂的过程或专门的材料.
研究的目的:
- 研究本地未经加工的粉作为简单的填充材料的潜力,以减轻涂层颗粒的压缩引起的损伤.
- 为了评估不同本土粉 (大米,塔皮奥卡,玉米,马) 对颗粒外层完整性和MUPS片的性能的影响.
主要方法:
- 准备了带有乙烯基纤维素或烯酸涂层的持续释放颗粒.
- 这些颗粒被压缩成MUPS片,使用含有微晶纤维素和不同度 (25%或40%w/w) 的本地粉的填充材料.
- 量化评估了MUPS片的抗拉强度和颗粒外层损坏的程度.
主要成果:
- 虽然粉降低了整体药片强度,但大米和塔皮奥卡粉最有效地减轻了颗粒外层的损伤 (减少10-44%,p < 0.008).
- 较高的粉度和压缩压力增强了这种保护性"缓冲"效应.
- 与乙烯基纤维素涂层颗粒相比,粉添加对烯酸涂层颗粒的益处更大.
结论:
- 本地粉,特别是大米和木,提供了一种简单而有效的方法,可以在MUPS片制造过程中减少颗粒外层的损伤.
- 缓冲效应归因于填充材料的特性,例如减少塑料变形和增加颗粒重新排列.
- 这种方法提供了一个可行的策略,以保护MUPS片中的持续释放涂层的完整性.
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