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基托桑基的二米里塞丁复合水凝显示持续释放和特殊的抗菌活性

Huanhuan Li¹, Yunhui Bao², Jian He¹

¹Key Laboratory of Hunan Forest Products and Chemical Industry Engineering, National and Local United Engineering Laboratory of Integrative Utilization of Eucommia ulmoides, Jishou University, Zhangjiajie 427000, China; College of Chemistry and Chemical Engineering, Jishou University, Jishou 416000, China.

International journal of biological macromolecules

|December 26, 2024

概括

这项研究开发了一种新型的基托桑水凝,以克服植物衍生抗菌剂二米瑞 (DMY) 的水溶性差. 水凝有效地释放了DMY,显示出99%以上的细菌抑制和持续释放130小时.

科学领域:

生物材料科学生物材料科学
药物运输药物运输药物运输
抗菌研究抗菌研究

背景情况:

植物衍生化合物如二米瑞 (DMY) 显示出对抗致病细菌的前景.
由于DMY的水溶性较差,限制了其治疗应用.
对于天然抗菌剂,需要有效的药物输送系统.

研究的目的:

开发一种基托基的水凝,用于封装和输送二米里西丁 (DMY).
为了评估物理化学性质,抗菌疗效,以及从水凝中持续释放的DMY.
探索这个系统在增强抗菌疗法的潜力.

主要方法:

在25°C的温度下快速合成一个碳氧甲基基托和甲基酸盐水凝.
使用扫描电子显微镜,FTIR和热重力测量分析进行表征.
针对Pseudomonas aeruginosa和Staphylococcus aureus的抗菌分析,以及体外药物释放研究.

主要成果:

水凝表现出有利的胀,可注射性,透明性和自我愈合特性.
用DMY加载的水凝在0.4mg/ml的DMY剂量下实现了99%以上的P. aeruginosa和S. aureus的抑制.
在各种水溶液 (酸性,性,PBS) 中持续释放DMY长达130小时.

结论:

基托基的水凝是二米瑞 (DMY) 的有效载体,解决了其溶解性问题.
开发的水凝显示出显著的抗菌活性和持续的药物释放.
该系统为植物衍生剂的协同抗菌应用提供了一个有前途的平台.

关键词:

具有抗菌活性,具有抗菌活性.基托桑基的水凝是基托桑基的水凝.这是一种二米里西丁 (dihydromyricetin).持续释放的释放是一种持续释放.

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