在聚乙烯微塑料和BDE153的急性同时暴露下,内细胞体,内细胞网,行动细胞骨受到了蒂拉皮亚肝脏的影响
Yao Zheng1, Jiajia Li1, Haojun Zhu1
1Wuxi Fishery College, Nanjing Agricultural University, Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture and Rural Affairs, Freshwater Fisheries Research Center (FFRC), Chinese Academy of Fishery Sciences (CAFS), Wuxi, Jiangsu 214081, China.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
|December 26, 2024
概括
纳米聚乙烯微塑料 (NP) 和BDE153的同时暴露会影响鱼的肝脏,影响内细胞和蛋白质加工等途径. 这项研究揭示了环境污染物组合对鱼类健康的毒理影响.
科学领域:
- 环境毒理学环境毒理学
- 水生毒理学 水生毒理学
- 生物化学 生物化学
背景情况:
- 纳米聚乙烯微塑料 (NP) 上的污染物表现出毒理学效应.
- 了解微塑料和持久有机污染物的联合影响对于水生生态系统至关重要.
研究的目的:
- 为了研究纳米聚乙烯微塑料 (NP) 和2,2',4,4',5,5'-hexabromodiphenyl (BDE153) 的同时暴露对幼鱼的毒理学影响.
- 分析肝脏病理学变化,酶活性,转录组学和蛋白质组学.
主要方法:
- 青少年鱼被暴露在对照物体,NP,BDE153或BDE153+NP组合物体中,持续了2,4天和8天.
- 评估肝脏组织病理学,酶活性 (抗氧化,能量,脂质代谢,促炎症,亡),转录组学 (KEGG通路分析) 和蛋白质组学.
主要成果:
- 同期暴露显著改变了与氧化应激,能量,脂质代谢,炎症和亡相关的酶活性.
- 组织学分析显示,暴露的鱼体内出现了核位移和真空球的形成.
- 基因基因基因基因基因基因基因基因 (KEGG) 途径分析表明,在内细胞结合中显著丰富,在内 плазма晶状体中蛋白质加工,以及对行为细胞骨的调节.
结论:
- 纳米聚乙烯微塑料和BDE153的同时暴露显著影响了鱼肝脏.
- 关键受影响的途径包括内细胞分裂,内等质网膜中的蛋白质加工,以及actin细胞骨的调节.
- 这项研究突出了鱼类中环境污染物的复杂毒理相互作用.
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