相关实验视频

Updated: Jun 4, 2025

Printing Thermoresponsive Reverse Molds for the Creation of Patterned Two-component Hydrogels for 3D Cell Culture

Printing Thermoresponsive Reverse Molds for the Creation of Patterned Two-component Hydrogels for 3D Cell Culture

Published on: July 10, 2013

3D打印的延长释放的化物胺片

Teodora Tasevska¹, Ivana Adamov², Nikola Geskovski¹

¹Institute of Pharmaceutical Technology, Center of pharmaceutical nanotechnology, Faculty of Pharmacy, Ss. Cyril & Methodius University in Skopje, Majka Tereza 47, 1000 Skopje, R North Macedonia.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

|December 26, 2024

概括

这项研究开发了使用半固体挤出 (SSE) 和数字光处理 (DLP) 3D打印技术的3D打印平板电脑 (printlets) 延长甲释放. 这两种方法都成功地产生了具有可控药物释放配置文件的印刷物.

科学领域:

制药技术制药技术制药技术
通过3D打印,可以实现3D打印.
药物运输药物运输药物运输

背景情况:

3D打印为个性化剂型提供了新的制造可能性.
延长释放配方对于提高治疗疗效和患者服药性至关重要.
甲 (HHT) 是一种广泛使用的利尿剂,使其成为释放研究的合适模型药物.

研究的目的:

设计和开发使用半固体挤出 (SSE) 和数字光处理 (DLP) 技术的3D打印平板电脑 (printlets).
从这些3D打印配方中研究甲 (HHT) 的延长释放特性.
描述印刷品并分析光聚合过程和药物释放动力学.

主要方法:

使用SSE和DLP3D打印制造了四种配方,具有不同的光启动器度.
风病学研究,里埃变换红外光谱法 (FTIR) 和拉曼光谱法用于表征.
在酸和酸缓冲器中进行了体外药物释放研究,随后进行了动态建模.

主要成果:

风病学研究确定了SSE和DLP打印的最佳配方 (F1_SSE和F1_DLP).
印刷品符合欧洲药典标准,用于剂量单位的统一性.
所有配方都表现出HHT的延长释放概况,并使用多种模型分析释放动力学.

结论:

无论是SSE还是DLP3D打印技术,都适用于生产延长释放化亚胺打印小片.
该研究成功地描述了印刷品的特征,并证实了HHT和辅助剂的存在.
开发的3D打印平板显示了控制药物输送应用的潜力.

关键词:

通过3D打印打印3D打印.数字光处理是数字光处理.延长释放的延长释放是一个问题.酸亚化是一种光聚合的光聚合方式.半固体挤出方式半固体挤出方式

更多相关视频

3D Printing of In Vitro Hydrogel Microcarriers by Alternating Viscous-Inertial Force Jetting

3D Printing of In Vitro Hydrogel Microcarriers by Alternating Viscous-Inertial Force Jetting

Published on: April 21, 2021

3D Printed Porous Cellulose Nanocomposite Hydrogel Scaffolds

3D Printed Porous Cellulose Nanocomposite Hydrogel Scaffolds

Published on: April 24, 2019

相关概念视频

Antihypertensive Drugs: Thiazide-Class Diuretics

Antihypertensive Drugs: Thiazide-Class Diuretics

Thiazide diuretics are sulfonamide derivatives featuring a benzothiadiazine ring system in their molecular structure. Based on this structure, thiazide diuretics can be categorized into two groups: thiazide-type and thiazide-like diuretics. Thiazide-type diuretics, including hydrochlorothiazide and chlorothiazide, consist of a benzothiadiazine backbone with an attached sulfonamide group. Thiazide-like diuretics, such as chlorthalidone and indapamide, lack the thiazide ring but demonstrate...

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...