干扰内分泌的化学物质,甲基,在环境相关的暴露中,促进了对下丘脑-垂体-甲状腺轴的危险影响
Damáris Barcelos Cunha Azeredo1, Denilson de Sousa Anselmo1, Ana Clara Falcão Veríssimo2
1Laboratório de Endocrinologia Experimental-LEEx, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Brazil; Programa de Pós-Graduação em Endocrinologia, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Brazil.
甲基帕拉本 (MP) 暴露会破坏雄性大鼠的甲状腺,改变其结构和激素基因表达. 这些发现表明,即使在低剂量中,也存在潜在的健康风险,这需要重新评估安全法规.
科学领域:
- 内分泌学 在内分泌学.
- 毒理学 毒理学 毒理学
- 环境健康 环境健康
背景情况:
- 甲基 (MP) 是消费品,食品和药品中常见的防腐剂.
- MP被认为是一种影响下丘脑-垂体-甲状腺 (HPT) 轴的内分泌干扰化学物质 (EDC).
- 关于MP对HPT轴的影响现有的研究是有限的,往往是矛盾的.
研究的目的:
- 为了研究亚急性甲基暴露对雄性大鼠HPT轴的影响.
- 评估MP给药后甲状腺的形态和基因表达变化.
- 评估MP对甲状腺平衡的潜在健康影响.
主要方法:
- 雄性大鼠被分为四组:对照组,并通过 gavage 暴露在MP中,剂量为3,30或300μg/kg/天,持续14天.
- 评估了甲状腺形态,包括卵泡区域,体区域,上皮区域和上皮高度.
- 分析了与甲状腺激素生物合成和间歇性原沉积相关的基因表达.
主要成果:
- 暴露于MP导致甲状腺形态的显著变化,其特征是卵泡和状区域减少,上皮高度降低.
- 观察到参与甲状腺激素生物合成的基因表达的变化.
- 在甲状腺中增加了间歇性原沉积,这表明有纤维变化.
结论:
- 低急性暴露于甲基帕拉显著影响甲状腺形态生理学和HPT轴恒温在雄性大鼠.
- 暴露于MP可以调节甲状腺功能,并可能造成健康风险.
- 目前对MP的安全规定可能需要重新考虑,因为即使是低剂量也可能引起有害影响.
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