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胰岛素德格卢德克在患有2型糖尿病的重症患者中:一项前性干预研究
Zainab Al Duhailib1, Hakeam Hakeam2, Ammar Almossalem3
1Critical Care Medicine Department, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
概括
在2型糖尿病 (DM) 危急病患者的胰岛素降糖治疗中,在2天内达到目标血糖水平. 这种超长效的胰岛素显示出良好的血糖控制和可变性,需要在重症监护室进行进一步的研究.
科学领域:
- 密集护理医学 密集护理医学
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 低血糖症显著恶化了患有糖尿病 (DM) 的重症患者的结果.
- 超长效的胰岛素insulin degludec在非急性护理环境中已经证明降低了低血糖和血糖 (BG) 变化.
- 关于在重症监护室 (ICU) 内的胰岛素脱格卢德克的疗效和安全性的数据有限.
研究的目的:
- 评估胰岛素降级剂对2型糖尿病诊断的危急病患者的血糖控制的影响.
- 评估胰岛素降级剂在重症监护环境中控制血糖水平的安全性和有效性.
主要方法:
- 一项前性,干预性研究,涉及2型DM的危急病患者.
- 患者接受了insulin degludec与常规胰岛素进行校正剂量.
- 每6小时对血糖水平进行监测,主要结果是BG水平在140-180 mg/dL目标范围内的百分比.
主要成果:
- 在155名注册患者中,28.5%的BG水平处于目标范围内.
- 在胰岛素降级剂治疗的第二天,BG水平中位数达到目标范围,并在一周内保持稳定.
- 严重的低血糖症发生在3.2%的患者中,BG的变化率为26% (变化系数).
结论:
- 与常规胰岛素校正剂量相结合的胰岛素降水剂在2型糖尿病重症患者中,在约四分之一的BG读数中实现了目标血糖控制.
- 从治疗的第二天开始,BG水平的中位数始终在目标范围内.
- 观察到与胰岛素降级剂的有利BG变异性表明潜在的好处,需要进一步调查临床结果.
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