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以天然内源物质为基础的载体,用于输送宏分子药物
1Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Chinese journal of natural medicines
|December 26, 2024
概括
自然内源材料 (NEM) 为先进的药物输送系统 (DDS) 提供生物相容性. 本综述探讨了基于NEM的DDS,以改善宏分子输送和治疗结果.
科学领域:
- 生物材料科学 生物材料科学
- 药物运输 药物运输 药物运输
- 纳米技术 纳米技术
背景情况:
- 自然内源材料 (NEMs) 具有固有的生物相容性,生物降解性和定位能力,最大限度地减少体内不良反应.
- 现有的药物输送系统 (DDS) 面临着因大小,结构,透性和环境不稳定性而导致的宏分子输送的挑战.
- 越来越多的NEM被用作DDS中的载体,以克服这些大分子疗法的局限性.
研究的目的:
- 提供基于NEM的药物输送策略的全面概述,用于宏分子输送.
- 分析基于NEM的DDS的优缺点.
- 为药物配方和治疗结果的未来制药创新提供见解.
主要方法:
- 关于在药物输送系统中使用的NEM的文献综述.
- 分析各种NEM类型,包括细胞衍生物,多糖,蛋白质,和核酸载体.
- 讨论基于NEM的DDS用于宏分子递送的优缺点.
主要成果:
- 作为宏分子输送的载体,NEM显示出显著的潜力,提高了效率并减少了副作用.
- 已经开发了各种基于NEM的DDS,展示了克服宏分子递送挑战的各种策略.
- NEM固有的特性有助于提高生物相容性和有针对性的交付.
结论:
- 基于NEM的DDS在制药科学中代表了一个有前途的前沿,用于有效的宏分子递送.
- 对NEM的进一步研究可以带来先进的药物配方,改善治疗疗效和患者的治疗结果.
- 了解NEM的好处和局限性对于优化未来的药物输送创新至关重要.
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