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[霍利德结点识别蛋白是脏清细胞癌的潜在预测和预后生物标志物]

Huahua Zhang¹, Qingyin Ta^1,2, Yun Feng¹

¹Medical Research and Experimental Center, Yan'an Medical College of Yan'an University, Yan'an 716000, China.

Nan fang yi ke da xue xue bao = Journal of Southern Medical University

|December 26, 2024

概括

霍利德结识蛋白 (HJURP) 在26种癌症中表达高,包括脏清细胞癌 (KIRC). 高HJURP表达与预后不佳和KIRC细胞恶性瘤增强相关.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物信息学是一种生物信息学.

背景情况:

霍莱德结识蛋白 (HJURP) 参与细胞分裂和癌症的进展.
它在脏清细胞癌 (KIRC) 中的特定作用及其与免疫反应的关联仍未完全阐明.

研究的目的:

研究HJURP在瘤发生,进展和免疫治疗反应中的作用.
分析HJURP表达模式及其与临床参数及其与各种癌症免疫细胞透的相关性,重点关注KIRC.

主要方法:

对TCGA,GTEx,SangerBox和TIMER 2.0数据库进行生物信息分析,以确定HJURP表达和预后价值.
在KIRC中使用LinkedOmics数据库进行与HJURP相关的基因分析.
在KIRC细胞中使用免疫组织化学,西部抹杀,qRT-PCR和基于细胞的测定 (增殖,迁移) 的实验验证.

主要成果:

在26种癌症中,HJURP过度表达,对5种癌症的存活率产生了负面影响,包括KIRC.
在瘤中,HJURP表达与临床阶段和免疫细胞透相关.
在KIRC中,HJURP显著升高,与TNM阶段,整体阶段和免疫透相关. 沉默HJURP抑制了KIRC细胞的增殖和迁移.

结论:

HJURP作为KIRC的潜在预后和免疫疗法反应指标.
升高的HJURP表达促进KIRC细胞中的恶性行为.

关键词:

霍利迪的结点识别蛋白质.脏脏清晰细胞癌瘤移民移民迁移迁移胰腺癌是一种癌症.它们的扩散和扩散.

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