在患有多发性硬化症的个体中,心血管血液动力反应对峰值运动的反应
Brooks A Hibner1, Natalia S Lima1, Sara R Sherman1
1Integrative Physiology Laboratory, University of Illinois at Chicago, Chicago, Illinois, USA.
Physiological reports
|December 26, 2024
概括
多发性硬化症 (MS) 患者和具有类似有氧能力的健康对照人群在运动高峰期表现出相似的血液动力学反应. 健身,而不是疾病本身,似乎决定了这些反应.
科学领域:
- 运动生理学 运动生理学
- 神经学 神经学
- 心血管健康 心血管健康
背景情况:
- 多发性硬化症 (MS) 是一种慢性神经疾病,通常与有氧能力 (VO2峰值) 的降低有关.
- 在患有多发性硬化症的个体中,对最大限度的运动的特定血液动力学反应在很大程度上仍未被描述.
- 目前尚不清楚MS中观察到的血液动力学差异是否可归因于疾病病理或身体健康下降.
研究的目的:
- 为了比较MS患者和健康对照者 (CON) 之间的高峰运动期间的血液动力学反应.
- 通过将参与者与峰值VO2相匹配,调查血液动力学反应中的任何差异是否与疾病状况或健康水平有关.
主要方法:
- 对患有MS (n=21) 和CON (n=21) 的参与者进行了最大增量周期运动测试.
- 评估了峰值有氧能力 (峰值VO2).
- 血液动力学变量包括心率 (HR),中风量 (SV),心脏输出量 (Q) 和平均动脉压 (MAP) 在整个运动测试中被测量.
主要成果:
- 在MS和CON组之间没有观察到VO2峰值的显著差异.
- 血液动力学变量 (HR,SV,Q,MAP) 从基线到峰值运动在两组中都同样增加.
- 在MS组中发现了HR的显著群体对时间的相互作用,这可以通过年龄来解释,但对于MAP,SV或Q没有发现这种相互作用.
结论:
- 患有多发性硬化和没有多发性硬化的人,当与峰值有氧能力相匹配时,对最大限度的运动表现出类似的血液动力学反应.
- 这些发现表明,身体健康水平是MS患者运动期间血液动力学反应的主要决定因素,而不是疾病本身.
更多相关视频
08:48Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
Published on: January 29, 2016
16.7K
09:04Skeletal Muscle Neurovascular Coupling, Oxidative Capacity, and Microvascular Function with 'One Stop Shop' Near-infrared Spectroscopy
Published on: February 20, 2018
12.4K
相关概念视频
01:20Exercise and Cardiovascular Response
640
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
640
01:17Exercise and Cardiac Output
691
Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...
Sustained exercise increases the muscles' oxygen demand, which can be...
691
01:22Cardiac Output II: Effect of Stroke Volume on Cardiac Output
505
Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
505
01:19Cardiac Output I:Effect of Heart Rate on Cardiac Output
472
Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart...
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart...
472
01:11Cardiac Output and Stroke Volume
2.4K
Cardiac output (CO) is an integral aspect of human physiology, reflecting the heart's efficiency and responsiveness to the body's needs. It represents the volume of blood that the left or right ventricle ejects into the aorta or pulmonary trunk each minute. The CO is calculated by multiplying the heart rate (HR)—the number of heartbeats per minute—by the stroke volume (SV)—the amount of blood pumped out with each heartbeat.
In an average resting adult male, the typical...
In an average resting adult male, the typical...
2.4K
01:23Assessment of the Cardiovascular System I: Subjective Data
236
A thorough health history and physical assessment are essential for identifying cardiovascular disease (CVD) symptoms and distinguishing them from other health issues.
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
236