莫林加油提取物对酸诱导的肺损伤的生化和组织学参数的影响
Umar Faruk Magaji1,2, Pınar Koroglu3, Melis Coremen4
1Faculty of Engineering, Department of Chemistry, Istanbul University- Cerrahpaşa, Avcilar, Istanbul, Türkiye.
Journal of molecular histology
|December 26, 2024
概括
莫林加提取物可以防止由甲 (VPA) 引起的肺部损伤. 这项研究表明Moringa.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 自然产品化学 自然产品化学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 酸 (VPA) 是一种抗药,可以通过有毒代谢产物引起组织损伤.
- 植物化学物质为各种疾病提供了有前途的治疗选择.
- 莫林加橄树具有已知的药理特性,包括肝保护和抗炎作用.
研究的目的:
- 研究Moringa oleifera乙醇提取物对VPA诱导的氧化性肺损伤的保护作用.
- 评估VPA和Moringa治疗后肺组织中的生化和组织学变化.
主要方法:
- 斯普雷格·道利雌性大鼠被分为四组:对照组,莫林加提取物,酸和酸+莫林加提取物.
- 鼠每天服用甲 (500毫克/公斤) 和/或莫林加提取物 (300毫克/公斤) 15天.
- 分析了肺组织的生物化学参数 (谷氨,抗氧化酶,氧化应激标志物,炎症蛋白质) 和组织病理变化.
主要成果:
- 甲的使用导致肺组织损伤增加,由生物化学和组织病理学发现证明.
- 用Moringa提取物治疗显著减少或预防VPA诱导的肺损伤.
- 莫林加提取物在生物化学和组织病理学参数上都表现出改善作用.
结论:
- 莫林加油提取物对酸诱导的肺损伤具有显著的保护和治疗作用.
- 莫林加的抗氧化和抗炎性质可能有助于其保护作用.
- 这项研究支持了Moringa作为减轻药物诱导肺损伤的天然干预措施的潜力.
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