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VZV IE4通过将其隔离到戈尔吉综合体来降低细胞表面MHC-I的调节

Yu Ye1, Shun Li2, Xu Yan3

  • 1College of Animal Science and Technology, Jiangxi Engineering Research Center for Animal Health Products, Jiangxi Agricultural University, Nanchang, Jiangxi, 330045, China.

Cellular and molecular life sciences : CMLS
|December 26, 2024
PubMed
概括

脊髓灰质炎病毒 (VZV) IE4蛋白在戈尔吉细胞中保留人类白细胞抗原C (HLA-C),降低主要基因相容性复合体I类 (MHC-I) 的调节. 突变IE4恢复MHC-I表达,揭示了一个VZV免疫逃避机制.

关键词:
在 HLA-C 的情况下.在IE4IE4IE4IE4IE4在MHC-I中,MHC-I是最重要的.VZVVVVVVZVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVV

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