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评估PAX1/JAM3甲基化用于HPV 16/18感染女性的分组

Jing Fei¹, Lingyun Zhai¹, Jing Wang²

¹Department of Gynecology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310003, China.

Clinical epigenetics

|December 26, 2024

概括

在CISCER甲基化测试准确地确定宫癌前病变在HPV16/18阳性女性. 这种测试可以减少不必要的结肠镜转诊和过度治疗宫癌查.

科学领域:

妇科瘤学妇科瘤学
分子诊断学分子诊断
宫癌查宫癌查

背景情况:

人类乳头瘤病毒 (HPV) 16/18阳性需要进一步调查,但目前的分类方法,如细胞学,具有诊断局限性.
对HPV 16/18阳性女性进行过度转诊可导致医疗费用增加和患者焦虑.

研究的目的:

评估PAX1/JAM3甲基化 (CISCER) 试验作为HPV 16/18感染妇女分拣策略的临床有效性.
将CISCER测试的诊断性能与细胞学和它们的组合进行比较,以识别宫内皮质瘤 (CIN).

主要方法:

一组334名HPV 16/18阳性转诊进行结肠镜检查的妇女被前性研究.
该研究比较了CISCER测试,细胞学和使用PAX1和JAM3基因甲基化分析的综合方法的分选性能.

主要成果:

与细胞学相比,CISCER测试在检测2级或严重 (CIN2+) 的宫内皮质瘤方面显示出显著更高的灵敏度 (89.0%) 和特异性 (95.3%).
CISCER测试显示曲线下面积很大 (0.921) 并确定了所有宫癌病例,在30岁或以上的女性中没有错过CIN3+病例.
一个阳性CISCER测试表明CIN2+的风险为89.0%,平均只需要1.12个转诊来检测一个CIN2+病例.

结论:

PAX1/JAM3甲基化检测 (CISCER测试) 是HPV 16/18阳性女性宫癌前病变的高度准确的生物标志物.
该CISCER测试作为一个有效的选工具,可能减少不必要的结肠镜转诊和随后的过度治疗.
实施CISCER测试可以优化宫癌查途径,改善资源配置.

关键词:

通过PAX1/JAM3甲基化.科尔波斯科比转诊情况在HPV 16/18阳性女性中,选的性能进行选.

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