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Updated: May 8, 2025

Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes
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使用脂质体-PROTAC方法进行PTGES3蛋白质分解

Shiwei Liu1, Fukang Yuan2,3, Hui Dong4

  • 1School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, China.

Biology direct
|December 26, 2024
PubMed
概括

研究人员开发了新的PROTACs (p-PROTACs) 来降解肝细胞癌 (HCC) 中的前列腺素E合成酶3 (PTGES3). 这种向蛋白质降解方法显示出通过削弱癌症恶性表型来治疗HCC的前景.

关键词:
肝细胞癌 肝细胞癌脂质细胞体中的脂肪体.在PTGES3中,酸蛋白解酶向的木乃伊.

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The Proteasome Structure01:17

The Proteasome Structure

The ubiquitin-proteasome pathway is a well-known mechanism utilized by eukaryotic cells to remove cytoplasmic proteins that are misfolded, damaged, or no longer needed. In this pathway, the protein that needs to be eliminated undergoes a process called ubiquitination, where a chain of ubiquitin molecules is attached to the 48th lysine residue of the target protein. This ubiquitin modification helps the proteasome distinguish between a target protein and a healthy protein.
The proteasome is an...
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