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免疫检查点抑制剂对乙型肝炎病毒感染的患者的影响

Hsien-Chen Mon1, Pei-Chang Lee1,2, Chen-Ta Chi1,2,3

  • 1Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.

Journal of the Chinese Medical Association : JCMA
|December 27, 2024
PubMed
概括

实现B型肝炎病毒 (HBV) 感染的功能治疗,以HBsAg损失为标志,至关重要. 结合免疫检查点抑制剂与核胺类同类药物的结合显示出HBsAg清除的前景.

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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