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Updated: Jun 4, 2025

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
09:42

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes

Published on: January 16, 2016

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基于多基质的系统:对catechol-O-methyltransferase的动力机制研究

Fangyuan Wang1, Xianglu Zhou1,2, Haonan Wang3

  • 1Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, China.

The FEBS journal
|December 27, 2024
PubMed
概括

这项研究通过光和质谱学阐明了Catechol-O-methyltransferase (COMT) 的有序序动力机制. 研究结果揭示了COMT如何与基质和Mg2+结合以催化甲基化,有助于开发新的COMT配体.

关键词:
甲基转移酶中的甲基转移酶 (Catechol-O-methyltransferase) 是一种甲基转移酶.光基板是一种光基板.运动机制的运动机制.质谱测量质谱测量质谱测量质谱测量质量测量质谱测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量分子动力学模拟模拟

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Benchtop Immobilized Metal Affinity Chromatography, Reconstitution and Assay of a Polyhistidine Tagged Metalloenzyme for the Undergraduate Laboratory08:02

Benchtop Immobilized Metal Affinity Chromatography, Reconstitution and Assay of a Polyhistidine Tagged Metalloenzyme for the Undergraduate Laboratory

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