泛免疫炎症值在患有多变性心肌病的患者中的临床影响
Levent Pay1, Ahmet Cagdas Yumurtas2, Seyda Dereli3
1Istanbul Haseki Training and Research Hospital, Department of Cardiology, Istanbul, Turkey.
Medeniyet medical journal
|December 27, 2024
概括
全免疫性炎症值 (PIV) 可以预测高性心肌病 (HCM) 患者的长期死亡率. 较高的PIV水平表明风险增加,表明PIV是潜在的查工具,用于HCM的不良结果.
科学领域:
- 心脏病学 心脏病学
- 炎症生物标志物 炎症生物标志物
- 医学预测 医学预测
背景情况:
- 增高性心肌病 (HCM) 需要改善对不良结果的风险分层.
- 炎症与HCM严重程度有关,需要新的预后标志物.
- 全免疫炎症值 (PIV) 是一种新的炎症标志物.
研究的目的:
- 在大量HCM患者中调查泛免疫炎症值 (PIV) 的预后价值.
- 确定PIV水平与HCM的长期死亡率之间的关联.
- 探索PIV作为一种潜在的查工具,用于识别高风险HCM患者.
主要方法:
- 一组389名HCM患者被追溯分析 (2004-2021年).
- 全免疫性炎症值 (PIV) 计算为 (中性细胞数 × 血小板数 × 单细胞数) / 淋巴细胞数.
- 患者被分为三个PIV三层,以评估长期死亡风险.
主要成果:
- 在平均55个半月的随访期间,47名 (12.1%) 患者死亡.
- 在PIV第三种动物中,长期死亡率增加了 (第7种第三种动物1,第12种第三种动物2,第28种第三种动物3).
- 多变量分析显示,与最低的PIV三位数相比,最高的PIV三位数的死亡风险高3.5倍.
结论:
- 升高的泛免疫炎症值 (PIV) 与HCM患者的长期死亡率增加有关.
- PIV显示出作为HCM风险分层的有价值查工具的潜力.
- 进一步的研究可能会验证PIV在治疗HCM患者的临床使用.
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