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呼出的氧化和唾液中异氨基酸是诊断职业性喘的补充工具
Virginie Doyen1, Nicolas Migueres2,3, Vera van Kampen4
1Service de Pneumologie, Centre Hospitalier Universitaire UCL Namur, Université Catholique de Louvain, Yvoir, Belgium.
Allergy
|December 27, 2024
概括
在职业暴露后比较排气的氧化 (FeNO) 和唾液中异氨基酸,在诊断职业性喘时显示出类似的准确性. 两种标记物的结合显著提高了诊断灵敏度.
科学领域:
- 肺部病理学 肺部病理学
- 职业医学 职业医学是专业的.
- 过敏和免疫学 过敏和免疫学
背景情况:
- 职业喘诊断缺乏对呼出的氧化 (FeNO) 和唾液中异氨基的比较数据.
- 特定的吸入挑战 (SIC) 用于识别职业喘触发因素.
研究的目的:
- 为了比较FeNO变化的诊断准确度与SIC期间的唾液异氨基变化的诊断准确度.
- 评估FeNO和唾液中异氨基酸作为职业性喘的生物标志物.
主要方法:
- 对321名接受SIC的受试者进行了回顾性多中心研究.
- 在SICs之前和24小时后测量了FeNO和唾液乙素.
- 156名受试者有积极的SIC结果.
主要成果:
- FeNO和唾液中的乙氨基酸表现出类似的诊断准确度 (AUC 0.78 和 0.81).
- 最佳值:FeNO≥13ppb,唾液中异氨基酸≥1.25%,产生高特异性但低灵敏度.
- 结合FeNO或唾液乙氨基酸增加,提高了77%的灵敏度.
结论:
- 暴露后增加的FeNO和/或唾液中异氨基的数量支持职业喘诊断.
- 评估这两种生物标志物补充了用于识别职业喘的螺旋计.
- 这些标记物是诊断支气管对职业药物反应的可靠工具.
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