在性结肠炎的血清生物标志物
Semih Sezer1, Selim Demirci1, Melisa Irem Kara2
1Health Sciences University Türkiye, Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Clinic of Gastroenterology, Ankara, Türkiye.
反应蛋白与淋巴细胞比率 (CLR) 和反应蛋白与白蛋白比率 (CAR) 有效检测性结肠炎 (UC) 活动. 中性粒细胞与淋巴细胞的比率 (NLR) 和血小板与淋巴细胞的比率 (PLR) 对UC疾病活性具有有限的诊断价值.
科学领域:
- 胃肠病学 胃肠病学
- 临床诊断 临床诊断 临床诊断
- 炎症性肠道疾病研究研究
背景情况:
- 性结肠炎 (UC) 诊断和活动评估通常依赖于侵入性内镜手术.
- 需要具有成本效益和易于应用的血清生物标志物来监测UC疾病活动.
- 目前的生物标志物需要进一步验证其在UC的诊断实用性.
研究的目的:
- 为了评估血清生物标志物的诊断有效性:中性粒细胞与淋巴细胞的比率 (NLR),血小板与淋巴细胞的比率 (PLR),C反应蛋白 (CRP) 与白蛋白的比率 (CAR) 以及CRP与淋巴细胞的比率 (CLR).
- 将这些生物标志物的实用性与内镜活性指数 (EAI) 进行比较,以确定UC疾病激活.
- 确定可靠的,非侵入性标志物来评估UC活动.
主要方法:
- 从UC患者和对照人群收集的血液测试的回顾性审查,与结肠镜检查同时采集.
- 计算NLR,PLR,CAR和CLR值的方法.
- 根据EAI得分将患者分为活跃UC (EAI ≥4),缓解UC (EAI <4) 和对照组.
主要成果:
- 该研究包括66名活跃UC患者,31名UC缓解,99名对照.
- 与对照组相比,在活跃和缓解UC患者中,CLR和CAR值显著更高 (p<0.001).
- CLR和CAR显示了活性UC的显著诊断价值,最佳切断值分别为>1.75和>0.11. 在PLR和NLR中,两组之间没有显著差异 (p>0.05).
结论:
- CLR和CAR是检测UC活动的敏感和特定生物标志物.
- 对于评估UC疾病活性来说,NLR和PLR具有较低的诊断价值.
- CAR和CLR为监测UC提供了一个有希望的,非侵入性的方法.
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