相关实验视频

Updated: May 8, 2025

Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans
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Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans

Published on: January 8, 2015

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激发性神经元易受子传播和激发性神经元损失在受子感染的小鼠中

Temuulen Erdenebat1, Yusuke Komatsu1, Nozomi Uwamori1

  • 1Laboratory of Veterinary Hygiene, Faculty of Veterinary Medicine, Graduate School of Infectious Diseases, Hokkaido University, Sapporo, Japan.

Frontiers in molecular neuroscience
|December 27, 2024
PubMed
概括

子疾病显示子蛋白 (PrPSc) 和病变的脑分布不均. 这项研究揭示了22L子菌株首选感染刺激神经元,导致它们的损失,特别是在丘脑中.

关键词:
在GABAergic神经元中.PrPSccc 这是一个很好的方法.激发性神经元的神经元谷氨酸作用神经元的神经元抑制性神经元抑制性神经元普里昂是什么意思?普里昂是什么意思?

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Bioluminescence Imaging of Neuroinflammation in Transgenic Mice After Peripheral Inoculation of Alpha-Synuclein Fibrils

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相关概念视频

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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