与心脑血管事件死亡风险相关的炎症和营养状况:来自NHANES的证据
Chengzhi Hou1, Xuanchun Huang1, Jie Wang1
1Guang'anmen Hospital, China Academy of Chinese Medicine Sciences, Beijing, China.
先进的肺癌炎症指数 (ALI) 有效预测了患有重大心血管和脑血管不良事件 (MACCE) 的患者的死亡风险. 监测ALI和实施抗炎策略可以降低死亡率.
科学领域:
- 心脏病学 心脏病学
- 营养科学 营养科学
- 免疫学 免疫学 免疫学
背景情况:
- 炎症和营养状况显著影响心脑血管事件幸存者的死亡风险.
- 识别预测性炎症和营养指数对于风险分层至关重要.
研究的目的:
- 评估主要不良心血管和脑血管事件 (MACCE) 幸存者的炎症和营养指数与死亡率之间的关系.
- 确定该人口中死亡率最具预测性的指数.
主要方法:
- 对MACCE幸存者的国家健康和营养检查调查 (NHANES) (1999-2010) 的队列数据的分析.
- 卡普兰-梅尔分析,接收器运行特征曲线和多变量调整的考克斯回归被用于评估七个炎症营养指数.
- 限制性立方线分析确定了最具预测性的指数,子组和灵敏度分析证实了模型的稳定性.
主要成果:
- 更高的高级肺癌炎症指数 (ALI) 和血清白蛋白水平与较低的全因和心血管死亡率有关.
- 增加的C-反应蛋白与淋巴细胞比率,中性粒细胞与血清白蛋白比率,中性粒细胞与淋巴细胞比率,全身免疫炎症指数 (SII) 和C-反应蛋白与较高的死亡率相关.
- ALI显示出与死亡率的非线性L形关系,最佳转折点在90度,表明风险最低.
结论:
- 常规监测ALI有助于临床医生评估MACCE幸存者的死亡风险.
- 抗炎疗法和营养支持对于降低这一患者群的死亡率至关重要.
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