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周血管入侵:乳腺癌的一个有前途的预后参数

Begüm Çalım Gürbüz¹, Tuçe Söylemez Akkurt¹, Handan Eren¹

¹Başakşehir Çam and Sakura City Hospital, Clinic of Medical Pathology, İstanbul, Türkiye.

Medeniyet medical journal

|December 27, 2024

概括

乳腺癌中的周周血管侵袭 (PVI) 与较大的瘤和更高级组织学有关. 识别PVI可能会改善乳腺癌患者的风险评估.

科学领域:

在瘤学瘤学.
病理学病理学病理学
癌症研究癌症研究

背景情况:

周血管侵袭 (PVI) 在癌症中越来越多地被认可,之前的研究集中在黑色素瘤上.
有限的数据存在于PVI的预后意义,特别是在乳腺癌背景下.

研究的目的:

评估PVI在乳腺癌的预后影响.
调查PVI与已确定的临床病理预后因素之间的相关性.

主要方法:

在2020年7月至2022年1月期间诊断的150名乳腺癌患者的分析.
评估PVI在血素和素染色幻灯片上的存在.
对PVI与临床病理参数相关性的统计分析 (p<0.05显著性).

主要成果:

瘤≥2.5厘米 (p=0.004) 的PVI更为普遍.
没有PVI与较低的组织学等级相关 (p=0.040).
淋巴血管侵袭 (LVI) 和围神经侵袭 (PNI) 在PVI中更频繁 (p=0.001,p=0.02).
没有PVI和外节延伸 (ENE) 显示出显著的关联 (p=0.035).

结论:

乳腺癌中的PVI与不良预后因素相关,包括瘤大小,组织学等级,LVI,PNI和ENE.
乳腺癌患者的PVI状态是改善乳腺癌患者风险分层的潜在指标.
进一步研究PVI在乳腺癌中的作用是有必要的.

关键词:

乳房乳房乳房血管形主义 (angiotropism) 是一种癌症癌症癌症癌症癌症周围血管的入侵.预后预后预后

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