在接受维生素D测试的儿童中,维生素D缺乏与生化异常的患病率
Mark J Bolland1, Paul Hofman2, Andrew Grey1
1Department of Medicine, University of Auckland, Auckland, New Zealand.
Clinical endocrinology
|December 27, 2024
概括
缺乏维生素D的并发症,如恶心,在测试25-氧维生素D (25OHD) 的儿童中很少见. 这些问题主要影响3岁以下的婴儿.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 营养科学 营养科学
- 临床生物化学 临床生物化学
背景情况:
- 儿童的维生素D缺乏 (VDD) 可以导致低血和恶心病.
- 与这些并发症相关的25-氧维生素D (25OHD) 精确水平尚不清楚.
研究的目的:
- 为了确定VDD并发症在儿童中的患病率.
- 为了确定25OHD度与低血和恶心病相关.
主要方法:
- 对儿童 (<18岁) 的30663个25OHD测量的回顾性分析.
- 生物化学标志物 (血清,PTH,ALP) 在25OHD测试后的6个月内被分析.
- 经确认的具有生化异常的VDD (VDDba) 定义为低,高PTH和高ALP.
主要成果:
- 分析了来自9516名儿童的12,858个符合条件的25OHD测量结果.
- 25OHD的中位数为61nmol/L;36%的<50nmol/L,10%的<25nmol/L.
- 临床确认的VDDba发生在所有测量的0.9%,主要发生在3岁以下的儿童中;8%的25OHD<25nmol/L的人证实了VDDba.
结论:
- 具有生化异常的VDD在接受25OHD测试的儿童中不常见.
- 这些并发症几乎完全影响3岁以下的儿童.
- 该研究澄清了VDD并发症影响的低患病率和特定的人口统计.
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