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Updated: Jun 4, 2025

A Semi-High-Throughput Adaptation of the NADH-Coupled ATPase Assay for Screening Small Molecule Inhibitors
10:28

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小分子ATM抑制剂作为潜在的癌症治疗:专利审查 (2003年至今)

Yan A Ivanenkov1,2, Alexander S Malyshev1,2, Victor A Terentiev1,2

  • 1P. Hertsen Moscow Oncology Research Institute, Moscow, Russian Federation.

Expert opinion on therapeutic patents
|December 27, 2024
PubMed
概括

ATAXIA-telangiectasia突变 (ATM) 激酶抑制剂是有前途的抗癌药物. 专利分析显示,imidazo[4,5-c]quinolinone支架是有效的,目前正在进行的临床试验正在探索它们与破坏DNA的疗法的结合.

关键词:
过敏症 telangiectasia 突变激酶 (ATM) 发生变异对DNA损伤反应 (DDRs) 的研究.癌症治疗疗法 癌症治疗双链断裂 (DSBs) 是一种抑制剂抑制剂的使用专利审查专利审查专利审查

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