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开发可立即释放的洛诺西卡姆药片配方,采用基于热挤压的三维打印技术

Aysel Yilmaz1, N Basaran Mutlu-Agardan1, Sevgi Takka1

  • 1Faculty of Pharmacy, Department of Pharmaceutical Technology, Gazi University, Etiler, Turkey.

Drug development and industrial pharmacy
|December 27, 2024
PubMed
概括

这项研究使用3D打印 (基于热挤出的化沉积模型) 开发了立即释放的洛诺西卡姆 (LRX) 片. 调整灌注密度和使用微晶纤维素II (MCC II) 有效控制药物释放以进行个性化治疗.

关键词:
通过3D打印打印3D打印.热挤出方式化沉积物的建模.立即释放 立即释放洛诺西卡姆 (lornoxicam) 是一种药物.低可溶性药物 低可溶性的药物这是一种微晶纤维素II.

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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