认知储备可以预测复发性复发性多发性硬化症的长期认知轨迹
Gianpaolo Maggi1, Manuela Altieri1, Mario Risi1
1Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli," Naples, Italy.
Multiple sclerosis (Houndmills, Basingstoke, England)
|December 27, 2024
概括
认知储备 (CR) 影响复发性复发性多发性硬化症 (pwRRMS) 患者的认知轨迹. 高CR与认知能力的改善有关,而低CR预测下降,强调需要CR增强干预措施.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 认知科学 认知科学
背景情况:
- 认知储备 (CR) 在复发性复发性多发性硬化症 (pwRRMS) 中在维持认知方面发挥着作用.
- 关于CR对 pwRRMS 的长期影响的先前研究是有限的.
研究的目的:
- 根据他们的CR,调查 pwRRMS的长期认知轨迹.
- 在pWRRMS中随着时间的推移识别认知变化的预测因素.
主要方法:
- 在基线和6.5年的随访后,对78 pwRRMS的神经心理评估.
- 使用词汇知识测试 (VOC) 分析CR.
- 统计分析包括ANCOVA和回归,对残疾和抑郁症进行控制.
主要成果:
- 高CR的PwRRMS表现出认知能力的改善,而低CR的PwRRMS表现出认知能力的下降.
- 词汇知识测试 (VOC) 的得分在整体样本中增加,并预测认知变化.
- 女性性别与VOC分数的增加有关.
结论:
- 通过VOC测量的认知储备可以增强,并预测 pwRRMS 中的长期认知结果.
- 鉴定由于低CR而面临风险的pwRRMS对于实施干预措施至关重要.
- 增强CR的策略可能会延迟pWRRMS的认知障碍.
相关概念视频
01:30Cognitive Development During Adulthood
50
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
50
01:27Language and Cognition
322
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
322
02:20Longitudinal Research
11.8K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
11.8K
01:35Long-term Potentiation
54.8K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
54.8K
01:05Long-term Depression
30.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
30.6K
01:24Working Memory
133
Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this...
133