在MS的疾病过程中的三角神经疼痛:来自多中心队列的诊断和治疗含义
Sini M Laakso1,2, Jiwon Oh3, Fasna Raufdeen3
1Department of Neurology, Brain Center, Helsinki University Hospital, Helsinki, Finland.
概括
多发性硬化症 (MS) 中的三神经疼痛 (TN) 可能表明活跃的疾病,而不仅仅是复发. 早期TN发病可能是MS的第一个症状,影响诊断和治疗.
科学领域:
- 神经学 神经学
- 神经免疫学 神经免疫学
- 临床神经科学 临床神经科学
背景情况:
- 三神经疼痛 (TN) 经常与多发性硬化症 (MS) 一起发生.
- 将TN归类为临床复发或活跃的MS疾病仍在争论中.
- 了解TN的作用对于管理MS进展至关重要.
研究的目的:
- 调查TN发病和多发性硬化症活动之间的关联.
- 为了确定TN呈现是否意味着复发或活跃的脱髓化疾病.
- 为MST患者的诊断和治疗策略提供信息.
主要方法:
- 在三个国际地点对多发性硬化症 (pwMS) 患者的TN诊断进行了回顾性分析.
- 评估TN作为最初的脱髓化症状.
- 与MS诊断和临床复发的发生相对TN发病时间的评估.
主要成果:
- 在0.9%-1.9%的pwMS中诊断出TN.
- 在9.9%的病例中,TN是第一个脱髓化的症状.
- 在20%的pwMS患者中,在TN发病后六个月内发生了临床复发.
结论:
- 在MS患者中TN发病应被视为活跃疾病的证据.
- 建议将TN评估纳入MS的诊断和治疗决策中.
- TN可能代表MS病理学的早期或持续的表现.
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